Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15152207 | 0.82 | MAOB (0.63) | KMT2AMEN1HTR2BKDM4ETP53 | |
| SCHEMBL8549607 | 0.79 | MAPT (0.50) | KMT2AMEN1HTR2BKDM4ETP53 | |
| SCHEMBL8788646 | 0.76 | CDC7 (0.59) | KMT2AMEN1KDM4ECYP1A2MAPT | |
| SCHEMBL9400551 | 0.75 | PRKCI (0.55) | KMT2AMEN1HTR2BKDM4ETP53 | |
| SCHEMBL31035921 | 0.75 | PRKCI (0.55) | KMT2AMEN1HTR2BKDM4ETP53 | |
| SCHEMBL24865228 | 0.75 | SMN1; SMN2 (0.51) | KMT2AMEN1HTR2BKDM4ETP53 | |
| SCHEMBL30336558 | 0.75 | SMN1; SMN2 (0.51) | KMT2AMEN1HTR2BKDM4ETP53 | |
| SCHEMBL16411810 | 0.75 | FAAH (0.46) | KMT2AMEN1HTR2BKDM4ETP53 | |
| SCHEMBL18029323 | 0.75 | HSD11B1 (0.53) | PRKCIMAOBFAAHCYP2A6 | |
| SCHEMBL22201673 | 0.74 | KDM1A (0.67) | KMT2AMEN1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534343-B1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-11-19 | — | — | EP | claimed |
| EP-0534343-A1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-03-31 | — | — | EP | claimed |
| US-5185350-A | For Alzheimer*s, memory dysfunctions, antidepressants, antiinflammatory agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-02-09 | — | — | US | claimed |
| JP-6001787-A | — | — | None | — | — | JP | disclosed |
| EP-0534343-B1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-11-19 | — | — | EP | disclosed |
| US-5631270-A | COGNITION ACTIVATORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5424322-A | Substituted pyridinylamino-1h-indole derivatives | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-13 | — | — | US | disclosed |
| US-5328918-A | Psychological disorders, antiinflammatory agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-07-12 | — | — | US | disclosed |
| JP-H061787-A | SUBSTITUTED PYRIDINYLAMINO-1H-INDOLE, 1H-INDAZOLE, 2H-INDAZOLE, BENZO(B)THIOPHENE AND 1,2-BENZISOTHIAZOLE | HOECHST ROUSSEL PHARMACEUT INC | 1994-01-11 | — | — | JP | disclosed |
| US-5246947-A | Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-09-21 | — | — | US | disclosed |
| US-5229401-A | Cognition activators; Alzheimer's disease; psychological disorders,e.g obsessive-compulsive; antidepressants; topical antinflammatory agent; skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0534343-A1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5185350-A | For Alzheimer*s, memory dysfunctions, antidepressants, antiinflammatory agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-02-09 | — | — | US | disclosed |