Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788895 | 0.94 | PPARG (0.64) | PPARG | |
| SCHEMBL8789745 | 0.83 | RORC (0.40) | PPARGRORCEDNRA | |
| SCHEMBL8788802 | 0.81 | PPARG (0.54) | PPARGEDNRAALOX5AP | |
| SCHEMBL7314683 | 0.81 | AGTR1 (0.58) | PPARGAGTR1AGTR2 | |
| SCHEMBL8848168 | 0.80 | AGTR1 (0.52) | PPARGAGTR1AGTR2 | |
| SCHEMBL8790319 | 0.78 | AGTR1 (0.67) | PPARGAGTR1AGTR2 | |
| SCHEMBL8790323 | 0.78 | AGTR1 (0.53) | AGTR1AGTR2 | |
| SCHEMBL8789960 | 0.77 | PPARG (0.47) | PPARG | |
| SCHEMBL8789490 | 0.75 | AGTR1 (0.51) | PPARGAGTR1AGTR2 | |
| SCHEMBL8789971 | 0.75 | PPARG (0.65) | PPARGEDNRAAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |
| EP-0468470-A1 | Benzimidazoles, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-01-29 | — | — | EP | disclosed |