Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788181 | 0.87 | NOS3 (0.30) | NOS3NOS1NOS2 | |
| SCHEMBL504020 | 0.81 | LMNA (0.50) | ALOX5APFEN1LMNATDP1DYRK1A | |
| SCHEMBL29693606 | 0.81 | LMNA (0.50) | ALOX5APFEN1LMNATDP1DYRK1A | |
| SCHEMBL13061958 | 0.78 | ALOX5AP (0.36) | ALOX5APFEN1F2RL3NOS3NOS1 | |
| SCHEMBL13351700 | 0.76 | MAPT (0.41) | LMNATDP1DYRK1AALDH1A1CYP3A4 | |
| SCHEMBL9189493 | 0.74 | NPC1 (0.46) | ALOX5APFEN1LMNADYRK1AALDH1A1 | |
| SCHEMBL11462527 | 0.73 | PIM1 (0.40) | LMNATDP1DYRK1AALDH1A1CYP3A4 | |
| SCHEMBL6826003 | 0.72 | TLR8 (0.35) | NOS3NOS1NOS2MEN1MAPT | |
| SCHEMBL26928579 | 0.70 | — | — | |
| SCHEMBL9433456 | 0.70 | ALDH1A1 (0.41) | LMNAALDH1A1F2RL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670656-A | Process for preparing pyrrolidinones | ZENECA LIMITED (GB) | 1997-09-23 | — | — | US | disclosed |
| EP-0763020-A1 | SUBSTITUTED PYRROLIDONE, THIAZOLIDONES OR OXAZOLIDONES AS HERBICIDES | ZENECA LIMITED (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033719-A1 | SUBSTITUTED PYRROLIDONE, THIAZOLIDONES OR OXAZOLIDONES AS HERBICIDES | ZENECA LIMITED (GB) | 1995-12-14 | — | — | WO | disclosed |