Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.40 |
| ▸ | ADH1C | P00326 | 1/20 | 0.40 |
| ▸ | ADH1A | P07327 | 1/20 | 0.40 |
| ▸ | ADH7 | P40394 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9171287 | 0.89 | ALDH1A1 (0.39) | ADH1BADH1CADH1AADH7ALDH1A1 | |
| SCHEMBL18626200 | 0.79 | ADH1B (0.47) | ADH1BADH1CADH1AADH7ALDH1A1 | |
| SCHEMBL7821065 | 0.70 | CYP2C19 (0.42) | ALDH1A1CYP2C19HIF1AKMT2ASLC6A2 | |
| SCHEMBL9141654 | 0.68 | ALDH1A1 (0.46) | ALDH1A1CYP2C19HIF1ACYP3A4KMT2A | |
| SCHEMBL10870263 | 0.68 | ALDH1A1 (0.38) | ALDH1A1CYP2C19KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10350106 | 0.68 | ALDH1A1 (0.46) | ALDH1A1CYP2C19CYP2C9KMT2ASLC6A2 | |
| SCHEMBL11633545 | 0.68 | KDM4E (0.47) | ALDH1A1CYP2C19HIF1AKMT2ASLC6A2 | |
| SCHEMBL24361875 | 0.67 | KMT2A (0.47) | ALDH1A1KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL418323 | 0.67 | TDP1 (0.47) | ALDH1A1CYP2C19HIF1AKMT2ASLC6A2 | |
| SCHEMBL27360247 | 0.67 | ALDH1A1 (0.44) | ALDH1A1CYP2C19CYP2C9KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669830-A4 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1997-02-26 | — | — | EP | disclosed |
| CN-1136278-A | Combination of bisphosphonates and growth hormone secretagogues | MERCK & CO INC (US) | 1996-11-20 | — | — | CN | disclosed |
| EP-0669830-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994011012-A1 | SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-05-26 | — | — | WO | disclosed |