Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789893 | 0.90 | MMP3 (0.43) | MMP7MMP8MMP12AGTR1AGTR2 | |
| SCHEMBL8789813 | 0.89 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9097072 | 0.88 | AGTR1 (0.44) | MMP7MMP8MMP12AGTR1AGTR2 | |
| Trifluoroacetic Acid SCHEMBL8788831 | 0.88 | AGTR1 (0.41) | MMP7MMP8MMP12AGTR1AGTR2 | |
| SCHEMBL8789304 | 0.88 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL8792314 | 0.86 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL9040518 | 0.83 | MMP7 (0.53) | MMP7MMP8MMP12AGTR1AGTR2 | |
| Trifluoroacetic Acid SCHEMBL9096666 | 0.81 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL9042243 | 0.81 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL9255199 | 0.79 | AGTR1 (0.45) | AGTR1AGTR2ALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | disclosed |
| EP-0468470-A1 | Benzimidazoles, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-01-29 | — | — | EP | disclosed |