Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 4/20 | 0.56 |
| ▸ | CDK4 | P11802 | 4/20 | 0.43 |
| ▸ | CCND1 | P24385 | 4/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | PRKACA | P17612 | 3/20 | 0.43 |
| ▸ | PRKACG | P22612 | 3/20 | 0.43 |
| ▸ | PRKACB | P22694 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845017 | 0.80 | PIM3 (0.79) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844918 | 0.80 | PIM3 (0.56) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844551 | 0.77 | KIF11 (0.61) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL12668330 | 0.73 | AHR (0.44) | PRKACAPRKACGPRKACBALDH1A1HSD17B10 | |
| SCHEMBL844356 | 0.72 | PIM3 (0.68) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844646 | 0.72 | PIM3 (1.00) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL31060188 | 0.72 | PIM3 (1.00) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL12427664 | 0.72 | AHR (0.56) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL22766133 | 0.71 | KIF11 (0.50) | PIM3CDK2PRKACAPRKACGPRKACB | |
| SCHEMBL879261 | 0.71 | PIM3 (0.46) | PIM3CDK4CCND1CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326649-B1 | NOVEL PYRROLO[2,3-a]CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-03-28 | — | — | EP | disclosed |