Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 3/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19732214 | 0.83 | PIM1 (0.36) | PIM3AHRKIF11PIM1PARP1 | |
| SCHEMBL844647 | 0.79 | PIM3 (0.46) | PIM3AHRCCNE2CDK4CCND1 | |
| SCHEMBL844649 | 0.79 | PIM3 (0.54) | PIM3AHRCCNE2CDK4CCND1 | |
| SCHEMBL20159135 | 0.77 | AHR (0.56) | AHRKEAP1PDPK1TNFRIPK1 | |
| SCHEMBL24562301 | 0.77 | KIF11 (0.58) | KEAP1KIF11 | |
| SCHEMBL844905 | 0.76 | PIM3 (0.55) | PIM3AHRCCNE2CDK4CCND1 | |
| SCHEMBL844635 | 0.76 | PIM3 (0.56) | PIM3AHRCCNE2CDK4CCND1 | |
| SCHEMBL844551 | 0.75 | KIF11 (0.61) | PIM3AHRCCNE2CDK4CCND1 | |
| SCHEMBL879036 | 0.71 | PIM3 (0.56) | PIM3AHRCCNE2CDK4CCND1 | |
| SCHEMBL1374474 | 0.69 | TNF (0.54) | PIM3AHRKEAP1PDPK1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326649-B1 | NOVEL PYRROLO[2,3-a]CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-03-28 | — | — | EP | disclosed |