Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.55 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10879740 | 0.91 | CDK8 (0.67) | CDK8CLK4AOC3LTB4RLTB4R2 | |
| SCHEMBL8789349 | 0.89 | CDK8 (0.72) | CDK8CLK4CYP19A1AOC3CYP1A2 | |
| SCHEMBL8789637 | 0.87 | UBE2N (0.54) | CDK8CLK4CYP19A1AOC3ATM | |
| SCHEMBL8790338 | 0.86 | CDK8 (0.63) | CDK8CLK4CYP19A1AOC3LTB4R | |
| SCHEMBL8789786 | 0.85 | CDK8 (0.56) | CDK8CLK4CYP19A1AOC3LTB4R | |
| SCHEMBL8790512 | 0.83 | KCNH2 (0.57) | CDK8CLK4LTB4RLTB4R2CYP1A2 | |
| SCHEMBL8790187 | 0.83 | LTB4R (0.59) | AOC3LTB4RLTB4R2ALDH1A1HTT | |
| SCHEMBL31072720 | 0.81 | TSHR (0.55) | CDK8CLK4LTB4RLTB4R2CYP1A2 | |
| SCHEMBL2770457 | 0.79 | CYP1A2 (0.81) | CYP19A1AOC3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14276933 | 0.79 | CYP3A4 (0.66) | CDK8CLK4AOC3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |