Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 10/20 | 0.59 |
| ▸ | LTB4R2 | Q9NPC1 | 10/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.53 |
| ▸ | PPIB | P23284 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790474 | 0.86 | ALOX5 (0.66) | LTB4RLTB4R2ALOX5AOC3PPIB | |
| SCHEMBL8790741 | 0.86 | MAPK1 (0.56) | LTB4RLTB4R2ALOX5AOC3PPIB | |
| SCHEMBL8790404 | 0.83 | CDK8 (0.60) | LTB4RLTB4R2AOC3ALDH1A1HTT | |
| SCHEMBL8835994 | 0.82 | SIGMAR1 (0.57) | LTB4RLTB4R2ALOX5SIGMAR1ALDH1A1 | |
| SCHEMBL17011382 | 0.80 | SIGMAR1 (0.46) | LTB4RLTB4R2SIGMAR1ALDH1A1GAA | |
| SCHEMBL9023046 | 0.80 | ALOX5 (0.55) | LTB4RLTB4R2ALOX5SIGMAR1AOC3 | |
| SCHEMBL8789557 | 0.79 | AOC3 (0.66) | SIGMAR1AOC3ALDH1A1 | |
| SCHEMBL8790580 | 0.78 | ALDH1A1 (0.61) | ALOX5PPIBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4497778 | 0.77 | PHLPP2 (0.45) | LTB4RLTB4R2SIGMAR1ALDH1A1GAA | |
| SCHEMBL14412444 | 0.77 | AOC3 (0.59) | ALOX5AOC3ALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0569380-A1 | ACRIDINE DERIVATIVES. | GLAXO LAB SA (FR) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992012132-A1 | ACRIDINE DERIVATIVES | LABORATOIRES GLAXO S.A. (FR) | 1992-07-23 | — | — | WO | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |