Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024969 | 0.88 | KCNH2 (0.73) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9629107 | 0.86 | KCNH2 (0.54) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL9628896 | 0.84 | KCNH2 (0.80) | KCNH2MAOB | |
| SCHEMBL9053806 | 0.83 | CYP3A4 (0.60) | KCNH2DRD3HRH3DRD2 | |
| SCHEMBL9628761 | 0.83 | KCNH2 (0.80) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8790478 | 0.82 | KCNH2 (0.76) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL21601503 | 0.79 | PARP10 (0.60) | PARP10DRD2 | |
| SCHEMBL25712466 | 0.79 | PARP10 (0.57) | PARP10DRD2MAOB | |
| SCHEMBL2022333 | 0.78 | KCNH2 (0.56) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL10726453 | 0.78 | LMNA (0.50) | KCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164429-B | Preparation method of dofetilide intermediate | 四川科瑞德凯华制药有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |