Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790264 | 0.85 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4CHDAC6HDAC3 | |
| SCHEMBL8791353 | 0.84 | TRPV1 (0.41) | ALDH1A1HPGDHDAC6HDAC3HDAC4 | |
| SCHEMBL8792333 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4CHDAC6HDAC1 | |
| SCHEMBL8790035 | 0.81 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4CHDAC6HDAC3 | |
| SCHEMBL8791041 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4CHDAC6HDAC3 | |
| SCHEMBL8791245 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CHDAC6HDAC3 | |
| SCHEMBL9845581 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CHDAC6HDAC3 | |
| SCHEMBL5817039 | 0.77 | KMT2A (0.62) | ALDH1A1HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL8791092 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4C | |
| SCHEMBL8790845 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4CHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |