Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790035 | 0.86 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4CGRIN1GRIN2B | |
| SCHEMBL8790046 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4CPOLBMAPT | |
| SCHEMBL8790264 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4CGRIN1GRIN2B | |
| SCHEMBL8791092 | 0.81 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4CPOLBMAPT | |
| SCHEMBL8791245 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8790795 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8790908 | 0.78 | DPP4 (0.38) | ALDH1A1HPGDGRIN1GRIN2BDPP4 | |
| SCHEMBL8792681 | 0.77 | ALDH1A1 (0.44) | ALDH1A1HPGDKDM4CKMT2AHDAC3 | |
| SCHEMBL8791041 | 0.77 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4CKMT2ANPC1 | |
| SCHEMBL8792333 | 0.76 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4CKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |