SCHEMBL8790806

SCHEMBL8790806

c1ccc(CN2CCCCCCCCNNN2)cc1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.42
GAA P10253 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
MAPT P10636 2/20 0.40
ALDH1A1 P00352 3/20 0.36
TSHR P16473 2/20 0.36
MEN1 O00255 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
KMT2A Q03164 1/20 0.36
HIF1A Q16665 1/20 0.36
HRH3 Q9Y5N1 2/20 0.36
LMNA P02545 1/20 0.36
MAPK1 P28482 1/20 0.36
CYP2D6 P10635 1/20 0.36
SLC6A3 Q01959 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8790515 0.95 SIGMAR1 (0.41) SIGMAR1GAAL3MBTL1MAPTALDH1A1
SCHEMBL1022743 0.90 SIGMAR1 (0.44) SIGMAR1GAAL3MBTL1MAPTALDH1A1
SCHEMBL6532984 0.83 SIGMAR1 (0.47) SIGMAR1GAAL3MBTL1ALDH1A1TSHR
SCHEMBL6272610 0.80 SIGMAR1 (0.52) SIGMAR1GAAL3MBTL1MAPTALDH1A1
SCHEMBL8329624 0.79 HRH3 (0.46) MAPTALDH1A1HRH3LMNA
SCHEMBL18768681 0.78 SIGMAR1 (0.53) SIGMAR1GAAL3MBTL1ALDH1A1TSHR
Hydrochloric Acid SCHEMBL1023667 0.72 ALDH1A1 (0.41) GAAL3MBTL1MAPTALDH1A1MEN1
SCHEMBL14423336 0.72 SIGMAR1 (0.55) SIGMAR1GAAALDH1A1TSHRMEN1
Pyrrolidine SCHEMBL15516038 0.69 SIGMAR1 (0.72) SIGMAR1ALDH1A1TSHRMEN1CYP2C9
SCHEMBL28265665 0.68 MEN1 (0.36) L3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0813523-A2 PREPARATION OF N-ARYLMETHYL AZIRIDINE DERIVATIVES, 1,4,7,10-TETRAAZACYCLODODECANE DERIVATIVES OBTAINED THEREFROM AND N-ARYLMETHYL-ETHANOL-AMINE SULPHONATE ESTERS AS INTERMEDIATES NYCOMED SALUTAR, INC. (US) 1997-12-29 EP disclosed
WO-1996028420-A2 PREPARATION OF N-ARYLMETHYL AZIRIDINE DERIVATIVES, 1,4,7,10-TETRAAZACYCLODODECANE DERIVATIVES OBTAINED THEREFROM AND N-ARYLMETHYL-ETHANOL-AMINE SULPHONATE ESTERS AS INTERMEDIATES NYCOMED SALUTAR, INC. (US) 1996-09-19 WO disclosed