Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790806 | 0.79 | SIGMAR1 (0.42) | HRH3ALDH1A1MAPTLMNA | |
| SCHEMBL8790515 | 0.75 | SIGMAR1 (0.41) | HRH3ALDH1A1MAPTLMNA | |
| SCHEMBL1805498 | 0.74 | KDM4E (0.71) | HRH3KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL3143167 | 0.74 | KDM4E (0.71) | HRH3KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL8329627 | 0.74 | KDM4E (0.71) | HRH3KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL2206628 | 0.72 | KDM4E (0.73) | HRH3KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL28801541 | 0.71 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL27171599 | 0.71 | KCNJ1 (0.58) | HRH3KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL1022743 | 0.69 | SIGMAR1 (0.44) | HRH3ALDH1A1MAPTLMNA | |
| SCHEMBL3156886 | 0.69 | KDM4E (0.73) | HRH3KDM4EALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736035-A4 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORP (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5847121-A | Production of nitro-benzyl-dota via direct peptide cyclization | NEORX CORPORATION (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0736035-A1 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5541287-A | DIAGNOSIS USING CYCLIC TRIPEPTIDES WITH NITROBENZYL 1,4,7,10-TETRAAZACYCLODODECANE-N,N*,N**,N***TETRAACETIC ACID BIOTIN CONJUGATE FORMED BY ALKYLATION AND MULTISTAGE PROCESS | NEORX CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1995015335-A2 | PRETARGETING METHODS AND COMPOUNDS | NEORX CORPORATION (US) | 1995-06-08 | — | — | WO | disclosed |