Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12882119 | 0.86 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2TSHRKDM4EPKM | |
| SCHEMBL7926733 | 0.86 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2TSHRKDM4EPKM | |
| SCHEMBL13074753 | 0.83 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2KDM4EPKMHSD17B10 | |
| SCHEMBL13543194 | 0.82 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2TSHRKDM4EPKM | |
| SCHEMBL237337 | 0.81 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2TSHRPKMLMNA | |
| SCHEMBL13545144 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2PKMHPGDRAB9A | |
| SCHEMBL2969896 | 0.79 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2PKMHPGDRAB9A | |
| SCHEMBL4847926 | 0.79 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2PKMHPGDRAB9A | |
| SCHEMBL1232799 | 0.79 | SMN1; SMN2 (0.75) | ALDH1A1SMN1; SMN2PKMRAB9ANPC1 | |
| SCHEMBL11683297 | 0.79 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2PKMHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4198029-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | University Health Network (CA) | 2023-06-21 | — | — | EP | disclosed |
| WO-2017027967-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2017-02-23 | — | — | WO | disclosed |
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |