Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790565 | 0.86 | ALDH1A1 (0.43) | ALDH1A1HPGDNPC1KMT2AMAPK8 | |
| SCHEMBL8790745 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HPGDNPC1KMT2AKDM4C | |
| SCHEMBL8792739 | 0.82 | ALDH1A1 (0.52) | ALDH1A1HPGDKMT2AKDM4CMAPK8 | |
| SCHEMBL8790883 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HPGDKMT2AKDM4CMAPK8 | |
| SCHEMBL8790380 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HPGDNPC1KMT2AKDM4C | |
| SCHEMBL8791619 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HPGDKMT2AKDM4CSMN1; SMN2 | |
| SCHEMBL8791168 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HPGDGAAMAPT | |
| Hydrochloric Acid SCHEMBL8973452 | 0.78 | ALDH1A1 (0.51) | ALDH1A1HPGDNPC1KMT2AKDM4C | |
| SCHEMBL8790106 | 0.78 | ALDH1A1 (0.36) | ALDH1A1HPGDKMT2AMAPK8MAPK10 | |
| SCHEMBL8791432 | 0.74 | ALDH1A1 (0.52) | ALDH1A1HPGDKMT2AKDM4CMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534258-B1 | Chiral oxazolines as dopants for liquid crystals mixtures | HOFFMANN LA ROCHE (CH) | 1997-05-21 | — | — | EP | disclosed |
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0441213-B1 | Chiral dioxolanes | HOFFMANN LA ROCHE (CH) | 1995-09-13 | — | — | EP | disclosed |
| EP-0534258-A1 | Chiral oxazolines as dopants for liquid crystals mixtures | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-31 | — | — | EP | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0441213-A2 | Chiral dioxolanes | F. HOFFMANN-LA ROCHE AG (CH) | 1991-08-14 | — | — | EP | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |