Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791225 | 0.86 | MAPK1 (0.41) | ALDH1A1HPGDMAPK8MAPK10LMNA | |
| SCHEMBL8791028 | 0.85 | KMT2A (0.32) | ALDH1A1HPGDLMNANPSR1MEN1 | |
| SCHEMBL8791633 | 0.82 | CYP2A6 (0.38) | ALDH1A1HPGDLMNAMAPTMEN1 | |
| SCHEMBL8791391 | 0.82 | RAB9A (0.46) | ALDH1A1MAPK8MAPK10MEN1TSHR | |
| SCHEMBL8790385 | 0.81 | MAPK8 (0.31) | ALDH1A1MAPK8MAPK10 | |
| SCHEMBL8790636 | 0.80 | CA2 (0.44) | ALDH1A1HPGDLMNANPSR1MEN1 | |
| SCHEMBL8791593 | 0.79 | HSD11B1 (0.36) | ALDH1A1HPGDMAPK8MAPK10LMNA | |
| SCHEMBL8791221 | 0.78 | PIK3C3 (0.36) | ALDH1A1HPGDPKMMAPT | |
| SCHEMBL8790903 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPK8MAPK10NPSR1 | |
| SCHEMBL8790825 | 0.76 | PLA2G10 (0.35) | ALDH1A1HPGDMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |