Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 6/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790791 | 0.92 | NR1H4 (0.33) | NR1H4NR1I2CYP2C9CYP2C19 | |
| Oxalic Acid SCHEMBL8790622 | 0.80 | HSD11B1 (0.41) | FABP4FABP5 | |
| Oxalic Acid SCHEMBL8790892 | 0.77 | CHRM2 (0.33) | FABP4FABP5 | |
| Oxalic Acid SCHEMBL8791269 | 0.75 | CHRM2 (0.43) | — | |
| Oxalic Acid SCHEMBL8791331 | 0.75 | — | — | |
| Oxalic Acid SCHEMBL9050512 | 0.75 | HSD11B1 (0.41) | FABP4FABP5 | |
| Oxalic Acid SCHEMBL8791078 | 0.74 | CHRM2 (0.44) | — | |
| Oxalic Acid SCHEMBL8790272 | 0.73 | CHRM2 (0.45) | — | |
| Oxalic Acid SCHEMBL9051385 | 0.73 | HSD11B1 (0.39) | — | |
| Oxalic Acid SCHEMBL8791341 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413545-B1 | Azabicyclic compounds | BEECHAM GROUP PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| US-5157160-A | Treatment of diseases of the nervous system | BEECHAM GROUP P.L.C. (GB) | 1992-10-20 | — | — | US | disclosed |
| US-5043343-A | Certain 5-substituted-1-aza-bicyclo[3.3.3]heptanes and their pharmaceutical compositions and methods | BEECHAM GROUP P.L.C. (GB) | 1991-08-27 | — | — | US | disclosed |
| EP-0413545-A2 | Azabicyclic compounds | Beecham Group p.l.c. (GB) | 1991-02-20 | — | — | EP | disclosed |