Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791593 | 0.83 | HSD11B1 (0.36) | KMT2ATSHRALDH1A1MEN1CYP1A2 | |
| SCHEMBL8791414 | 0.81 | ALDH1A1 (0.43) | L3MBTL1KMT2AHTTALDH1A1HPGD | |
| SCHEMBL8791221 | 0.76 | PIK3C3 (0.36) | ALDH1A1GAAKDM4EMAPTHPGD | |
| SCHEMBL8791570 | 0.73 | KMT2A (0.33) | L3MBTL1KMT2AHTTTSHRUSP2 | |
| SCHEMBL8791028 | 0.71 | KMT2A (0.32) | KMT2ATSHRALDH1A1MEN1KDM4E | |
| SCHEMBL8791208 | 0.70 | MAPK8 (0.34) | HTTALDH1A1HPGDNPSR1 | |
| SCHEMBL8790766 | 0.70 | KMT2A (0.48) | KMT2ATSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL8790392 | 0.68 | MAPK8 (0.33) | TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL8792325 | 0.68 | MAPK8 (0.33) | ALDH1A1 | |
| SCHEMBL8520184 | 0.67 | MAPT (0.40) | L3MBTL1KMT2ATSHRALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |