Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 10/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790660 | 0.94 | ADRB2 (0.45) | ADRB2CCR2PPARGADRB3SERPINE1 | |
| SCHEMBL8791505 | 0.94 | ADRB2 (0.45) | ADRB2CCR2PPARGADRB3SERPINE1 | |
| SCHEMBL8790987 | 0.94 | ADRB2 (0.46) | ADRB2CCR2ADRB3SERPINE1ADRB1 | |
| SCHEMBL8793357 | 0.93 | ADRB2 (0.44) | ADRB2CCR2PPARGADRB3SERPINE1 | |
| SCHEMBL8791862 | 0.92 | ADRB3 (0.48) | ADRB2ADRB3ADRB1ADRA2AADRA2B | |
| SCHEMBL8791149 | 0.92 | ADRB2 (0.44) | ADRB2CCR2ADRB3SERPINE1ADRB1 | |
| SCHEMBL8793387 | 0.91 | ADRB2 (0.46) | ADRB2CCR2PPARGADRB3SERPINE1 | |
| SCHEMBL8791797 | 0.90 | PPARG (0.46) | ADRB2CCR2PPARGADRB3SERPINE1 | |
| SCHEMBL8791273 | 0.88 | ADRB2 (0.46) | ADRB2CCR2PPARGADRB3SERPINE1 | |
| SCHEMBL8790482 | 0.87 | ADRB2 (0.46) | ADRB2CCR2ADRB3SERPINE1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703911-B1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1997-07-02 | — | — | EP | disclosed |
| EP-0703911-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029290-A1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |