Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794212 | 0.81 | HTT (0.32) | TSHRHSD17B10ALDH1A1MAPK1KDM4E | |
| SCHEMBL8793023 | 0.78 | SIRT2 (0.39) | HSD17B10CYP1A2KMT2AMAPTALDH1A1 | |
| SCHEMBL8793900 | 0.74 | TSHR (0.35) | TSHRHSD17B10CYP1A2KMT2AMAPT | |
| SCHEMBL1123239 | 0.68 | KDM4E (0.44) | KMT2AALDH1A1MEN1KDM4EHTT | |
| SCHEMBL3349385 | 0.68 | KDM4E (0.44) | KMT2AALDH1A1MEN1KDM4EHTT | |
| SCHEMBL1122649 | 0.68 | KDM4E (0.44) | KMT2AALDH1A1MEN1KDM4EHTT | |
| SCHEMBL6994471 | 0.68 | ALDH1A1 (0.53) | HSD17B10KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL8792427 | 0.66 | LMNA (0.31) | — | |
| SCHEMBL8793891 | 0.66 | KMT2A (0.31) | KMT2A | |
| SCHEMBL8792164 | 0.65 | TSHR (0.34) | TSHRHSD17B10CYP1A2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452151-B1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO INC (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5334591-A | Useful in the treatment of ocular hypertension and glaucoma | MERCK & CO., INC. (US) | 1994-08-02 | — | — | US | disclosed |
| US-5308863-A | Carbonic anhydrase inhibitors | MERCK & CO., INC. (US) | 1994-05-03 | — | — | US | disclosed |
| EP-0543497-A1 | Tricyclic thienothiopyrans as antiglancoma agents | MERCK & CO. INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5175284-A | Glaucoma | MERCK & CO., INC. (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0452151-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1991-10-16 | — | — | EP | disclosed |