Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8793900 | 0.88 | TSHR (0.35) | TSHRALDH1A1CYP1A2CYP2C19PKM | |
| SCHEMBL9422935 | 0.80 | CYP1A2 (0.39) | TSHRALDH1A1CYP1A2CYP2C19PKM | |
| SCHEMBL8794410 | 0.79 | — | — | |
| SCHEMBL8794406 | 0.77 | — | — | |
| SCHEMBL9581563 | 0.77 | ALDH1A1 (0.40) | TSHRALDH1A1TDP1KMT2AKDM4E | |
| SCHEMBL6996021 | 0.68 | MEN1 (0.43) | TSHRALDH1A1CYP1A2CYP2C19MAPT | |
| SCHEMBL8792427 | 0.67 | LMNA (0.31) | — | |
| SCHEMBL9581983 | 0.66 | KAT2B (0.36) | ALDH1A1USP2ALOX15TDP1CYP4F2 | |
| SCHEMBL8792741 | 0.65 | TSHR (0.38) | TSHRALDH1A1CYP1A2CYP2C19PKM | |
| SCHEMBL13575460 | 0.65 | CYP4F2 (0.50) | TSHRALDH1A1CYP1A2CYP2C19CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452151-B1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO INC (US) | 1997-07-16 | — | — | EP | disclosed |
| EP-0452151-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1991-10-16 | — | — | EP | disclosed |