Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 5/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1832214 | 0.88 | TRPA1 (0.44) | PREPTRPA1ESR1ESR2LMNA | |
| SCHEMBL26639423 | 0.83 | ESR1 (0.58) | ESR1ESR2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL28088631 | 0.81 | PREP (0.39) | PREPESR1ESR2HTR2AHRH1 | |
| SCHEMBL28931304 | 0.81 | RIPK1 (0.43) | TRPA1ALDH1A1LMNAHSD17B10HTR2A | |
| SCHEMBL5609564 | 0.81 | HRH1 (0.40) | PREPHTR2AHRH1SLC7A5PARP1 | |
| SCHEMBL9181327 | 0.80 | PREP (0.46) | PREPALDH1A1SLC6A3 | |
| SCHEMBL22349242 | 0.79 | ESR1 (0.42) | TRPA1ESR1ESR2LMNAHTR2A | |
| SCHEMBL4122236 | 0.79 | ESR1 (0.42) | TRPA1ESR1ESR2LMNAHTR2A | |
| SCHEMBL11133727 | 0.79 | SLC7A5 (0.54) | HTR2AHRH1SLC7A5SLC6A2SLC6A4 | |
| SCHEMBL27260853 | 0.79 | SIGMAR1 (0.41) | HTR2AHRH1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0541407-B1 | Nitrogen containing bicyclic derivatives, method for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-02-26 | — | — | EP | disclosed |
| US-5384322-A | Prolylendopeptidase inhibitors; Alzheimer*s disease; antidepressant and anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1995-01-24 | — | — | US | disclosed |
| US-5286732-A | Prolylendopeptidase-inhibitors; administering for treatment and prevention of memory disorders for aging | ADIR ET COMPAGNIE (FR) | 1994-02-15 | — | — | US | disclosed |
| EP-0541407-A1 | Nitrogen containing bicyclic derivatives, method for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-05-12 | — | — | EP | disclosed |