Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744893 | 0.71 | ALDH1A1 (0.34) | L3MBTL1ALDH1A1POLB | |
| SCHEMBL8744885 | 0.71 | ALDH1A1 (0.44) | MAPK1SMN1; SMN2KMT2AL3MBTL1MEN1 | |
| SCHEMBL5698524 | 0.70 | AKR1C3 (0.49) | MAPK1SMN1; SMN2KMT2ANT5EL3MBTL1 | |
| SCHEMBL5698531 | 0.70 | AKR1C3 (0.49) | MAPK1SMN1; SMN2KMT2ANT5EL3MBTL1 | |
| SCHEMBL9510821 | 0.69 | SMN1; SMN2 (0.48) | MAPK1SMN1; SMN2KMT2ANT5EMEN1 | |
| SCHEMBL9510815 | 0.69 | SMN1; SMN2 (0.48) | MAPK1SMN1; SMN2KMT2ANT5EMEN1 | |
| SCHEMBL4098980 | 0.67 | AKR1C3 (0.46) | MAPK1SMN1; SMN2KMT2ANT5EMEN1 | |
| SCHEMBL14855270 | 0.66 | ALDH1A1 (0.61) | MAPK1SMN1; SMN2L3MBTL1PTGS2ALDH1A1 | |
| Formic Acid SCHEMBL27456543 | 0.65 | KMT2A (0.47) | MAPK1SMN1; SMN2KMT2ANT5EMEN1 | |
| SCHEMBL12443129 | 0.65 | SMN1; SMN2 (0.89) | SMN1; SMN2KMT2AL3MBTL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797575-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996018626-A1 | IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-20 | — | — | WO | disclosed |