Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407409 | 0.88 | NPC1 (0.45) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL5698524 | 0.83 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL5698531 | 0.83 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL1150860 | 0.79 | LTA4H (0.47) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL5219690 | 0.75 | ALDH1A1 (0.67) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL14565694 | 0.75 | ALDH1A1 (0.67) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL5219694 | 0.75 | ALDH1A1 (0.67) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL3256335 | 0.75 | ALDH1A1 (0.41) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL14565691 | 0.73 | SMN1; SMN2 (0.49) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 | |
| SCHEMBL5216896 | 0.73 | SMN1; SMN2 (0.49) | AKR1C3AKR1C2AKR1C1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962834-B2 | Modulators of amyloid beta | HOFFMANN-LA ROCHE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2257541-B1 | MODULATORS FOR AMYLOID BETA | HOFFMANN LA ROCHE (CH) | 2013-08-14 | — | — | EP | disclosed |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | HOFFMANN-LA ROCHE INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | HOFFMANN-LA ROCHE, INC. | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215759-A1 | MODULATORS FOR AMYLOID BETA | APP, PSEN1, APOB | AKR1C3 3565/4885AKR1C2 3485/4885AKR1C1 3383/4885 |
| US-20130190302-A1 | MODULATORS OF AMYLOID BETA | APP, PSEN1, APOB | AKR1C3 3603/4885AKR1C2 3530/4885AKR1C1 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.