Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794785 | 0.81 | GRIN2D (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL8795023 | 0.80 | CCNE2 (0.44) | FEN1CCNB2CDK1CCNB1CDK5 | |
| SCHEMBL8794533 | 0.77 | DYRK1A (0.48) | DYRK1ACCNB2CDK1CCNB1CDK5 | |
| SCHEMBL8796139 | 0.76 | ABCG2 (0.54) | MAPK10RIPK1PARP1GABRPGABRD | |
| SCHEMBL7412080 | 0.73 | ALDH1A1 (0.48) | CCNB2CDK1CCNB1CDK5CDK5R1 | |
| SCHEMBL31619545 | 0.71 | ERCC5 (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL6009055 | 0.71 | ERCC5 (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL6326783 | 0.70 | ALDH1A1 (0.55) | PARP1GAAKDM4E | |
| SCHEMBL21885155 | 0.69 | ESR1 (0.56) | DYRK1APBRM1GPR17GABRPGABRD | |
| SCHEMBL22541361 | 0.68 | IDO1 (0.47) | DYRK1AERCC5FEN1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |