Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | MAP2 | P11137 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8794433 | 0.77 | GRIN2D (0.44) | DYRK1AKDM4ECDK5CDK5R1AURKB | |
| SCHEMBL8794516 | 0.76 | NQO2 (0.50) | DYRK1ADAOKDM4ECDK9 | |
| SCHEMBL7412080 | 0.73 | ALDH1A1 (0.48) | KDM4ECDK5CDK5R1GSK3BALOX5 | |
| SCHEMBL31054360 | 0.72 | DYRK1A (0.46) | DYRK1ADAOMAP2KDM4ECDK5 | |
| SCHEMBL8794931 | 0.70 | KDM4E (0.48) | DYRK1AMAP2KDM4EGSK3BCA12 | |
| SCHEMBL8794489 | 0.70 | PARP1 (0.49) | DAOKDM4ECDK5CDK5R1GSK3B | |
| SCHEMBL15617244 | 0.69 | DYRK1A (0.62) | DYRK1AMAP2KDM4ECDK5CDK5R1 | |
| SCHEMBL14566728 | 0.68 | DAO (0.53) | DYRK1ADAOMAP2KDM4ECDK5 | |
| SCHEMBL8794785 | 0.68 | GRIN2D (0.45) | DYRK1AKDM4ECDK5CDK5R1GSK3B | |
| SCHEMBL19215410 | 0.67 | CYP1A2 (0.52) | DYRK1ADAOMAP2KDM4ECDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |