SCHEMBL8794833

SCHEMBL8794833

COc1cc2c(cc1O)CNC2

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.49
MAOA P21397 7/20 0.47
CYP2D6 P10635 1/20 0.47
HSD17B10 Q99714 1/20 0.47
ALDH1A1 P00352 1/20 0.47
ACHE P22303 2/20 0.46
PTGS2 P35354 1/20 0.45
CYP3A4 P08684 1/20 0.43
MAPT P10636 1/20 0.43
DRD1 P21728 1/20 0.42
DRD5 P21918 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1011463 0.87 HTR2A (0.53) CHRNA7MAOACYP2D6HSD17B10ALDH1A1
SCHEMBL29702351 0.87 HTR2A (0.53) CHRNA7MAOACYP2D6HSD17B10ALDH1A1
SCHEMBL3505675 0.87 HTR2A (0.53) CHRNA7MAOACYP2D6HSD17B10ALDH1A1
SCHEMBL32690214 0.87 HTR2A (0.53) CHRNA7MAOACYP2D6HSD17B10ALDH1A1
Hydrochloric Acid SCHEMBL5600419 0.86 MAOA (0.54) CHRNA7MAOACYP2D6HSD17B10ALDH1A1
Hydrochloric Acid SCHEMBL5600142 0.86 MAOA (0.54) CHRNA7MAOACYP2D6HSD17B10ALDH1A1
SCHEMBL1705264 0.84 CYP3A4 (0.59) CHRNA7MAOAALDH1A1ACHECYP3A4
SCHEMBL30040451 0.84 CYP3A4 (0.59) CHRNA7MAOAALDH1A1ACHECYP3A4
Hydrochloric Acid SCHEMBL31193341 0.82 CYP3A4 (0.56) CHRNA7MAOAALDH1A1CYP3A4MAPT
Hydrochloric Acid SCHEMBL9871800 0.82 CYP3A4 (0.56) CHRNA7MAOAALDH1A1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0634401-B1 MDR reversal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5639887-A MULTIDRUG RESISTANT CELLS; INCREASE CELL SENSITIVITY TO ANTICANCER AGENTS AMERICAN CYANAMID COMPANY (US) 1997-06-17 US disclosed
US-5561141-A POTENTIATE ACTIVITY OF ANTITUMOR AGENTS AMERICAN CYANAMID COMPANY (US) 1996-10-01 US disclosed
US-5550149-A SULFUR-CONTAINING COMPOUNDS THAT ARE EFFECTIVE IN POTENTIATING THE ACTIVITY OF CHEMOTHERAPEUTIC ANTI-CANCER AGENTS BY INCREASING SENSITIVITY OF MULTI-DRUG RESISTANT CELLS AMERICAN CYANAMID COMPANY (US) 1996-08-27 US disclosed
US-5387685-A MDR reversal agents AMERICAN CYANAMID COMPANY 1995-02-07 US disclosed
EP-0634401-A1 MDR reversal agents AMERICAN CYANAMID COMPANY (US) 1995-01-18 EP disclosed