Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.52 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.52 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.52 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.52 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.52 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.52 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.52 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.52 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 4/20 | 0.50 |
| ▸ | DRD5 | P21918 | 4/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32690214 | 1.00 | HTR2A (0.53) | HTR2AHTR2CHTR2BMAOACYP2D6 | |
| SCHEMBL29702351 | 1.00 | HTR2A (0.53) | HTR2AHTR2CHTR2BMAOACYP2D6 | |
| SCHEMBL3505675 | 1.00 | HTR2A (0.53) | HTR2AHTR2CHTR2BMAOACYP2D6 | |
| Hydrochloric Acid SCHEMBL5600419 | 0.98 | MAOA (0.54) | HTR2AHTR2CHTR2BMAOACYP2D6 | |
| Hydrochloric Acid SCHEMBL5600142 | 0.98 | MAOA (0.54) | HTR2AHTR2CHTR2BMAOACYP2D6 | |
| SCHEMBL8794833 | 0.87 | CHRNA7 (0.49) | MAOACYP2D6HSD17B10ALDH1A1DRD1 | |
| SCHEMBL29788066 | 0.87 | HTR2A (0.61) | HTR2AHTR2CHTR2BMAOA | |
| SCHEMBL329913 | 0.87 | HTR2A (0.61) | HTR2AHTR2CHTR2BMAOA | |
| Hydrochloric Acid SCHEMBL915156 | 0.85 | HTR2A (0.59) | HTR2AHTR2CHTR2BMAOA | |
| Hydrochloric Acid SCHEMBL7075718 | 0.84 | HTR2A (0.58) | HTR2AHTR2CHTR2BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308059-B1 | 1,2,3,4-TETRAHYDROISOQUINOLINE ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1992-09-09 | — | — | EP | claimed |
| EP-0308059-A1 | 1,2,3,4-Tetrahydroisoquinoline antiarrhythmic agents | Pfizer Limited (GB) | 1989-03-22 | — | — | EP | claimed |
| CN-115872985-B | 1,2,3, 4-Tetrahydroisoquinoline-thiophene derivative and preparation method thereof | 赣江中药创新中心 | 2025-01-14 | — | — | CN | disclosed |
| CN-115872985-A | 1,2,3, 4-tetrahydroisoquinoline-thiophene derivative and preparation method thereof | 赣江中药创新中心 | 2023-03-31 | — | — | CN | disclosed |
| EP-2714682-B1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES | UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO (IT) | 2016-03-16 | — | — | EP | disclosed |
| US-9095631-B2 | Tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases | UNIVERSITA DEGLI STUDI DI BARI “ALDO MORO” (IT) | 2015-08-04 | — | — | US | disclosed |
| US-20140112868-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES | UNIVERSITA' DEGLI STUDI DI BARI "ALDO MORO" (IT) | 2014-04-24 | — | — | US | disclosed |
| US-20110212956-A1 | Pyrazolopyrimidines for treating CNS disorders | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-09-01 | — | — | US | disclosed |
| US-7985753-B2 | Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-07-26 | — | — | US | disclosed |
| EP-2295439-A1 | Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine | Merz Pharma GmbH & Co. KGaA (DE) | 2011-03-16 | — | — | EP | disclosed |
| EP-2054416-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2011-01-05 | — | — | EP | disclosed |
| US-5561141-A | POTENTIATE ACTIVITY OF ANTITUMOR AGENTS | AMERICAN CYANAMID COMPANY (US) | 1996-10-01 | — | — | US | disclosed |
| US-5550149-A | SULFUR-CONTAINING COMPOUNDS THAT ARE EFFECTIVE IN POTENTIATING THE ACTIVITY OF CHEMOTHERAPEUTIC ANTI-CANCER AGENTS BY INCREASING SENSITIVITY OF MULTI-DRUG RESISTANT CELLS | AMERICAN CYANAMID COMPANY (US) | 1996-08-27 | — | — | US | disclosed |
| WO-1995032967-A1 | AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-12-07 | — | — | WO | disclosed |
| US-5387685-A | MDR reversal agents | AMERICAN CYANAMID COMPANY | 1995-02-07 | — | — | US | disclosed |
| EP-0634401-A1 | MDR reversal agents | AMERICAN CYANAMID COMPANY (US) | 1995-01-18 | — | — | EP | disclosed |
| EP-0308059-B1 | 1,2,3,4-TETRAHYDROISOQUINOLINE ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1992-09-09 | — | — | EP | disclosed |
| US-4965360-A | Tetrahydroisoquinoline compounds | PFIZER INC. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4882337-A | Tetrahydroisoquinoline antiarrhythmic agents | PFIZER INC. (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0308059-A1 | 1,2,3,4-Tetrahydroisoquinoline antiarrhythmic agents | Pfizer Limited (GB) | 1989-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140112868-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES | ABCB1, ABCG2, ABCC2 | HTR2A 479/4885HTR2C 789/4885HTR2B 714/4885 |
| US-20110212956-A1 | Pyrazolopyrimidines for treating CNS disorders | GRM5, GRM3, GRM1 | HTR2A 133/4885HTR2C 50/4885HTR2B 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.