Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.48 |
| ▸ | XPO1 | O14980 | 2/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394467 | 0.82 | RAPGEF4 (0.59) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| SCHEMBL440959 | 0.80 | CES2 (0.58) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| SCHEMBL330354 | 0.78 | MAPT (0.55) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| SCHEMBL998165 | 0.78 | IDO1 (0.46) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| SCHEMBL16628066 | 0.78 | MAPT (0.50) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| SCHEMBL16274236 | 0.78 | MAPT (0.45) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| SCHEMBL2094730 | 0.78 | MAPT (0.45) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| Hydrochloric Acid SCHEMBL999258 | 0.76 | IDO1 (0.48) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| SCHEMBL7685858 | 0.76 | MAPT (0.44) | MAPTRAPGEF4XPO1GPR35IDO1 | |
| Hydrochloric Acid SCHEMBL1968509 | 0.76 | MAPT (0.53) | MAPTRAPGEF4XPO1GPR35IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |