Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090248 | 0.87 | CDK1 (0.57) | RXFP1CDK1CCNB1ALOX5MEN1 | |
| SCHEMBL8794998 | 0.82 | GAA (0.58) | ALOX5MEN1MAPTKMT2ALMNA | |
| SCHEMBL7528152 | 0.82 | MAP2 (0.64) | RXFP1CDK1CCNB1ALOX5MEN1 | |
| SCHEMBL28265675 | 0.81 | HTR6 (0.51) | RXFP1CDK1CCNB1ALOX5MEN1 | |
| SCHEMBL8793753 | 0.80 | KDM4E (0.57) | RXFP1ALOX5MEN1MAPTKMT2A | |
| SCHEMBL10461607 | 0.80 | KMT2A (0.51) | ALOX5MEN1MAPTKMT2ALMNA | |
| SCHEMBL11735067 | 0.78 | CDK1 (0.51) | RXFP1CDK1CCNB1ALOX5MEN1 | |
| SCHEMBL8794573 | 0.78 | ALOX15 (0.51) | RXFP1MEN1MAPTKMT2AALOX15 | |
| SCHEMBL10464236 | 0.77 | ALOX15 (0.47) | ALOX5MEN1MAPTKMT2AALOX15 | |
| SCHEMBL18079064 | 0.77 | RXFP1 (0.68) | RXFP1CDK1CCNB1ALOX5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |