Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796911 | 0.96 | AURKA (0.52) | AURKARPS6KB1ALDH1A1USP2CYP1A2 | |
| SCHEMBL8796055 | 0.92 | RPS6KB1 (0.47) | AURKARPS6KB1ALDH1A1PDGFRBEGFR | |
| SCHEMBL8796031 | 0.92 | AURKA (0.48) | AURKARPS6KB1ALDH1A1PDGFRBEGFR | |
| SCHEMBL8795496 | 0.88 | AURKA (0.49) | AURKARPS6KB1ALDH1A1PDGFRBEGFR | |
| SCHEMBL8796758 | 0.87 | AURKA (0.44) | AURKARPS6KB1ALDH1A1USP2CYP1A2 | |
| SCHEMBL8795542 | 0.87 | AURKA (0.47) | AURKARPS6KB1ALDH1A1PDGFRBEGFR | |
| SCHEMBL8796285 | 0.85 | SRC (0.47) | USP2CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL8795332 | 0.85 | HTT (0.48) | AURKARPS6KB1ALDH1A1USP2CYP1A2 | |
| SCHEMBL7525212 | 0.84 | MAPT (0.52) | AURKAALDH1A1PDGFRBEGFRSMN1; SMN2 | |
| SCHEMBL8796096 | 0.84 | RPS6KB1 (0.46) | AURKARPS6KB1ALDH1A1PDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |