SCHEMBL8795351

SCHEMBL8795351

CONC(=O)c1ccc2[nH]cc(C(=O)N3CCN(c4ncccc4NC(C)C)CC3)c2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.49
ADORA3 P0DMS8 1/20 0.49
CHRM1 P11229 1/20 0.49
MAOA P21397 1/20 0.49
TBXA2R P21731 1/20 0.49
OPRM1 P35372 1/20 0.49
MDH1 P40925 1/20 0.49
KCNH2 Q12809 1/20 0.49
ABCG2 Q9UNQ0 1/20 0.49
HDAC1 Q13547 2/20 0.38
HDAC6 Q9UBN7 2/20 0.38
GFER P55789 1/20 0.38
CHRM2 P08172 1/20 0.38
ALDH1A1 P00352 4/20 0.37
HSD17B10 Q99714 4/20 0.37
HPGD P15428 3/20 0.37
KDM4E B2RXH2 2/20 0.37
TLR8 Q9NR97 2/20 0.36
TLR7 Q9NYK1 2/20 0.36
TLR9 Q9NR96 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8985918 0.87 ALDH1A1 (0.52) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL5109661 0.87 ADRA2A (0.53) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9036267 0.86 ADRA2A (0.53) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8985916 0.86 ADRA2A (0.53) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037116 0.85 ADRA2A (0.53) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9036400 0.85 ADRA2A (0.53) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037435 0.84 ADRA2A (0.50) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9037801 0.84 GFER (0.55) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9039041 0.83 ADRA2A (0.49) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL9038498 0.83 ADRA2A (0.55) ADRA2AADORA3CHRM1MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993001181-A1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS THE UPJOHN COMPANY (US) 1993-01-21 WO claimed
US-5599930-A Substituted indoles as anti-AIDS pharmaceuticals THE UPJOHN COMPANY (US) 1997-02-04 US disclosed
EP-0594702-B1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS UPJOHN CO (US) 1997-01-29 EP disclosed
WO-1993001181-A1 SUBSTITUTED INDOLES AS ANTI-AIDS PHARMACEUTICALS THE UPJOHN COMPANY (US) 1993-01-21 WO disclosed