Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988256 | 0.77 | HPGD (0.55) | HRH2HRH1ALDH1A1KDM4EHPGD | |
| SCHEMBL8795446 | 0.77 | CYP2D6 (0.34) | KCNH2HRH3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4378023 | 0.76 | CYP3A4 (0.40) | KCNH2HRH3HRH2HRH1KDM4E | |
| SCHEMBL4384300 | 0.75 | LTA4H (0.51) | KCNH2HRH3LTA4HPPARGPPARA | |
| SCHEMBL7961327 | 0.75 | RAB9A (0.43) | KCNH2HRH3ALDH1A1HPGDRAB9A | |
| SCHEMBL4380966 | 0.75 | NQO1 (0.45) | KCNH2HRH3ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7987297 | 0.75 | HRH3 (0.54) | KCNH2HRH3ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6206282 | 0.74 | KCNH2 (0.61) | KCNH2HRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL7977252 | 0.74 | NOS1 (0.47) | KCNH2LTA4HPPARA | |
| SCHEMBL8793384 | 0.73 | CYP3A4 (0.36) | KCNH2HRH3HRH1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | claimed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |