Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796603 | 0.92 | LMNA (0.44) | EGFRMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL7525212 | 0.88 | MAPT (0.52) | AURKAEGFRMAPTALDH1A1L3MBTL1 | |
| SCHEMBL8796308 | 0.88 | EGFR (0.47) | EGFRMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL8796103 | 0.87 | AURKA (0.56) | AURKARPS6KB1EGFRMAPTALDH1A1 | |
| SCHEMBL8796911 | 0.87 | AURKA (0.52) | AURKARPS6KB1EGFRALDH1A1PDGFRB | |
| SCHEMBL7523791 | 0.84 | MAPT (0.53) | EGFRMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL8796240 | 0.84 | EGFR (0.45) | EGFRMAPTALDH1A1PDGFRBCYP1A2 | |
| SCHEMBL8796234 | 0.84 | PIK3CA (0.45) | EGFRMAPTPDGFRBCYP1A2 | |
| SCHEMBL8795595 | 0.83 | EGFR (0.49) | EGFRPDGFRBCLK4 | |
| SCHEMBL8796541 | 0.83 | EGFR (0.47) | EGFRMAPTALDH1A1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |