Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796234 | 0.99 | PIK3CA (0.45) | EGFRPDGFRBPIK3CAMAPTMAPK1 | |
| SCHEMBL8796335 | 0.93 | MAPK1 (0.45) | EGFRPDGFRBPIK3CAMAPK1ERBB2 | |
| SCHEMBL8796603 | 0.92 | LMNA (0.44) | EGFRPDGFRBMAPTKDM4EALDH1A1 | |
| SCHEMBL7522631 | 0.89 | MAPT (0.55) | EGFRPDGFRBMAPTMAPK1CYP1A2 | |
| SCHEMBL7518944 | 0.88 | MAPT (0.54) | EGFRPDGFRBMAPTMAPK1CYP1A2 | |
| SCHEMBL8795810 | 0.88 | EGFR (0.49) | EGFRPDGFRBPIK3CAMAPTMAPK1 | |
| SCHEMBL8796096 | 0.88 | RPS6KB1 (0.46) | EGFRPDGFRBPIK3CAKDM4EALDH1A1 | |
| SCHEMBL8796375 | 0.87 | EGFR (0.48) | EGFRPDGFRBPIK3CAMAPTMAPK1 | |
| SCHEMBL8795890 | 0.87 | PIK3CA (0.47) | EGFRPDGFRBPIK3CAKDM4EALDH1A1 | |
| SCHEMBL8825977 | 0.86 | MAPK1 (0.55) | EGFRMAPTMAPK1ERBB2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0485636-B1 | INDOLE DERIVATIVE | TORAY INDUSTRIES (JP) | 1997-03-12 | — | — | EP | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |
| EP-0735026-A1 | Method for the production of isoquinoline derivatives and their use as intermediates in the preparation of indole derivatives | TORAY INDUSTRIES, INC. (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5539119-A | MULTISTAGE FORMATION BY OXIDATION, REDUCING A CARBAMATE TO FORM AN ENAMINE, FORMING AN OXIDE | TORAY INDUSTRIES, INC. (JP) | 1996-07-23 | — | — | US | disclosed |
| US-5244904-A | Immunorepressant, analgesic | TORAY INDUSTRIES, INC. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0485636-A1 | INDOLE DERIVATIVE | TORAY INDUSTRIES, INC. (JP) | 1992-05-20 | — | — | EP | disclosed |