Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796240 | 0.93 | EGFR (0.45) | MAPK1EGFRPDGFRBERBB2PIK3CA | |
| SCHEMBL8796234 | 0.92 | PIK3CA (0.45) | MAPK1EGFRPDGFRBERBB2PIK3CA | |
| SCHEMBL8796603 | 0.90 | LMNA (0.44) | L3MBTL1EGFRPDGFRBSMN1; SMN2CDK1 | |
| SCHEMBL7528397 | 0.89 | MAPK1 (0.57) | MAPK1L3MBTL1HTR6EGFRPDGFRB | |
| SCHEMBL8796483 | 0.89 | PDGFRB (0.45) | MAPK1L3MBTL1HTR6EGFRPDGFRB | |
| SCHEMBL8796323 | 0.89 | EGFR (0.48) | MAPK1L3MBTL1EGFRPDGFRBSIRT6 | |
| SCHEMBL8796541 | 0.86 | EGFR (0.47) | MAPK1EGFRPDGFRB | |
| SCHEMBL8795620 | 0.85 | EGFR (0.45) | MAPK1L3MBTL1EGFRPDGFRBSIRT6 | |
| SCHEMBL8825977 | 0.85 | MAPK1 (0.55) | MAPK1L3MBTL1EGFRERBB2 | |
| SCHEMBL8795306 | 0.84 | PDGFRB (0.45) | EGFRPDGFRBAURKARPS6KB1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |