Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795810 | 0.92 | EGFR (0.49) | EGFRPDGFRBL3MBTL1POLBMCL1 | |
| SCHEMBL8796375 | 0.91 | EGFR (0.48) | EGFRPDGFRBL3MBTL1POLBMCL1 | |
| SCHEMBL8796008 | 0.91 | EGFR (0.48) | EGFRPDGFRBL3MBTL1POLBALDH1A1 | |
| SCHEMBL8796323 | 0.90 | EGFR (0.48) | EGFRPDGFRBL3MBTL1POLBALDH1A1 | |
| SCHEMBL8796409 | 0.90 | PDGFRB (0.49) | EGFRPDGFRBL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL8796541 | 0.90 | EGFR (0.47) | EGFRPDGFRBALDH1A1MAPK1MAPT | |
| SCHEMBL7519162 | 0.89 | CYP1A2 (0.47) | EGFRPDGFRBALDH1A1USP2CYP1A2 | |
| SCHEMBL7514367 | 0.89 | MAPT (0.48) | EGFRPDGFRBL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8796603 | 0.89 | LMNA (0.44) | EGFRPDGFRBL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8796758 | 0.88 | AURKA (0.44) | EGFRPDGFRBL3MBTL1POLBMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |