Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207671 | 0.83 | HTR2A (0.36) | ALDH1A1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL6622199 | 0.82 | MAOB (0.34) | ALDH1A1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL8149465 | 0.82 | ADRB1 (0.41) | CYP3A4SLC6A3 | |
| SCHEMBL7310726 | 0.81 | IDO1 (0.39) | IDO1TDO2ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL8795978 | 0.79 | TRPA1 (0.32) | — | |
| SCHEMBL8796135 | 0.79 | TSHR (0.34) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6132657 | 0.77 | KDM4E (0.31) | MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL6619259 | 0.77 | ACP3 (0.45) | ALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL153891 | 0.76 | PTGFR (0.32) | CYP3A4 | |
| SCHEMBL8794946 | 0.76 | ENPP2 (0.35) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |