Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796541 | 0.92 | EGFR (0.47) | PDGFRBEGFRMAPTALDH1A1MAPK1 | |
| SCHEMBL8796008 | 0.91 | EGFR (0.48) | PDGFRBEGFRALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8796323 | 0.91 | EGFR (0.48) | PDGFRBEGFRALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8795810 | 0.91 | EGFR (0.49) | PDGFRBEGFRMAPTALDH1A1MAPK1 | |
| SCHEMBL8796308 | 0.90 | EGFR (0.47) | PDGFRBEGFRMAPTALDH1A1MAPK1 | |
| SCHEMBL8796375 | 0.90 | EGFR (0.48) | PDGFRBEGFRMAPTALDH1A1MAPK1 | |
| SCHEMBL8796457 | 0.90 | PDGFRB (0.46) | PDGFRBEGFRMAPTALDH1A1MAPK1 | |
| SCHEMBL8796694 | 0.90 | PDGFRB (0.46) | PDGFRBEGFRMAPTALDH1A1MAPK1 | |
| SCHEMBL8795620 | 0.88 | EGFR (0.45) | PDGFRBEGFRMAPTALDH1A1MAPK1 | |
| SCHEMBL8795560 | 0.87 | ACHE (0.47) | PDGFRBEGFRALDH1A1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |