Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796008 | 0.93 | EGFR (0.48) | EGFRPDGFRBMAPK1KDM4EHPGD | |
| SCHEMBL8796323 | 0.92 | EGFR (0.48) | EGFRPDGFRBMAPK1KDM4EHPGD | |
| SCHEMBL8795810 | 0.92 | EGFR (0.49) | EGFRPDGFRBMAPK1KDM4EMAPT | |
| SCHEMBL8796409 | 0.92 | PDGFRB (0.49) | EGFRPDGFRBMAPK1MAPTRAB9A | |
| SCHEMBL8796375 | 0.91 | EGFR (0.48) | EGFRPDGFRBMAPK1KDM4EMAPT | |
| SCHEMBL8796308 | 0.90 | EGFR (0.47) | EGFRPDGFRBMAPK1KDM4EMAPT | |
| SCHEMBL8796457 | 0.89 | PDGFRB (0.46) | EGFRPDGFRBACHEMAPK1KDM4E | |
| SCHEMBL8795620 | 0.89 | EGFR (0.45) | EGFRPDGFRBMAPK1MAPTHPGD | |
| SCHEMBL8795701 | 0.89 | PDE5A (0.49) | MAPK1KDM4EPKMLMNAHTT | |
| SCHEMBL8796694 | 0.88 | PDGFRB (0.46) | EGFRPDGFRBMAPK1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758653-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-02-19 | — | — | EP | disclosed |