Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 12/20 | 0.41 |
| ▸ | RARB | P10826 | 11/20 | 0.41 |
| ▸ | RARG | P13631 | 10/20 | 0.41 |
| ▸ | RXRA | P19793 | 9/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796232 | 0.88 | RXRA (0.39) | RARARARBRARGRXRARXRG | |
| SCHEMBL8796246 | 0.86 | RARA (0.41) | RARARARBRARGRXRARXRG | |
| SCHEMBL8796237 | 0.86 | RARA (0.41) | RARARARBRARGRXRARXRG | |
| SCHEMBL8795874 | 0.85 | RARA (0.44) | RARARARBRARGRXRARXRG | |
| SCHEMBL8796886 | 0.80 | PLA2G4A (0.45) | RARARARBRARGCYP3A4KDM4E | |
| SCHEMBL8796891 | 0.80 | PLA2G4A (0.45) | RARARARBRARGCYP3A4KDM4E | |
| SCHEMBL8795997 | 0.80 | RARA (0.46) | RARARARBRARGRXRARXRG | |
| SCHEMBL8796712 | 0.78 | RXRA (0.44) | RARARARBRARGRXRARXRG | |
| SCHEMBL3819796 | 0.74 | RARB (0.60) | RARARARBRARGRXRARXRG | |
| SCHEMBL8796646 | 0.74 | CYP3A4 (0.41) | RARARARBRARGRXRARXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |