Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 3/20 | 0.32 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | RARG | P13631 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796517 | 1.00 | PLA2G4A (0.39) | PLA2G4ARXRARXRBRXRGCYP26A1 | |
| SCHEMBL8796651 | 0.87 | CYP3A4 (0.41) | PLA2G4ARXRARXRBRXRGCYP26A1 | |
| SCHEMBL8796646 | 0.87 | CYP3A4 (0.41) | PLA2G4ARXRARXRBRXRGCYP26A1 | |
| SCHEMBL8796136 | 0.84 | NPC1 (0.39) | — | |
| SCHEMBL8796142 | 0.84 | NPC1 (0.39) | — | |
| SCHEMBL8796491 | 0.83 | RARG (0.38) | PLA2G4ARXRARXRBRXRGCYP26A1 | |
| SCHEMBL8796493 | 0.83 | RARG (0.38) | PLA2G4ARXRARXRBRXRGCYP26A1 | |
| SCHEMBL8796156 | 0.82 | PLA2G4A (0.44) | PLA2G4ARXRARXRBRXRGCYP26A1 | |
| SCHEMBL8796149 | 0.82 | PLA2G4A (0.44) | PLA2G4ARXRARXRBRXRGCYP26A1 | |
| SCHEMBL8796232 | 0.81 | RXRA (0.39) | RXRARXRBRXRGCYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |