Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | BTN3A1 | O00481 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796142 | 1.00 | NPC1 (0.39) | NPC1RAB9AL3MBTL1POLBGPR52 | |
| SCHEMBL8796507 | 0.84 | PLA2G4A (0.39) | — | |
| SCHEMBL8796517 | 0.84 | PLA2G4A (0.39) | — | |
| SCHEMBL8796270 | 0.84 | MAPT (0.45) | NPC1RAB9AL3MBTL1POLBGPR52 | |
| SCHEMBL8796260 | 0.84 | MAPT (0.45) | NPC1RAB9AL3MBTL1POLBGPR52 | |
| SCHEMBL8795690 | 0.81 | KMT2A (0.36) | NPC1MAPTKDM4ESMN1; SMN2TP53BP1 | |
| SCHEMBL8795697 | 0.81 | KMT2A (0.36) | NPC1MAPTKDM4ESMN1; SMN2TP53BP1 | |
| SCHEMBL9258569 | 0.78 | PLA2G4A (0.39) | ALDH1A1 | |
| SCHEMBL8795840 | 0.77 | PLA2G4A (0.40) | POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8795834 | 0.77 | PLA2G4A (0.40) | POLBMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |