Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 6/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797492 | 0.93 | ENPP2 (0.42) | ENPP2ROCK2SLC15A1SMN1; SMN2MAPK1 | |
| SCHEMBL8797073 | 0.91 | ALDH1A1 (0.41) | ENPP2ROCK2SLC15A1SMN1; SMN2MAPK1 | |
| SCHEMBL8798522 | 0.84 | DHODH (0.45) | SMN1; SMN2MAPK1L3MBTL1ALDH1A1PPARG | |
| SCHEMBL14525072 | 0.84 | SLC15A1 (0.44) | ENPP2ROCK2SLC15A1SMN1; SMN2MAPK1 | |
| SCHEMBL14268347 | 0.84 | SLC15A1 (0.44) | ENPP2ROCK2SLC15A1SMN1; SMN2MAPK1 | |
| SCHEMBL14268348 | 0.84 | SLC15A1 (0.44) | ENPP2ROCK2SLC15A1SMN1; SMN2MAPK1 | |
| SCHEMBL394264 | 0.79 | CPA1 (0.49) | CYP1A2PPARGPPARA | |
| SCHEMBL14268346 | 0.75 | KLK7 (0.47) | PPARGPPARAMEN1KMT2A | |
| SCHEMBL14268345 | 0.75 | KLK7 (0.47) | PPARGPPARAMEN1KMT2A | |
| SCHEMBL392816 | 0.74 | TACR3 (0.47) | ALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807114-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1997-11-19 | — | — | EP | disclosed |