Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15571625 | 0.87 | AKR1C3 (0.37) | MAOAMAOBAKR1C3PTGS2 | |
| SCHEMBL15570939 | 0.87 | PTGS2 (0.37) | MAOAMAOBAKR1C3PTGS2 | |
| SCHEMBL2223120 | 0.85 | PTGS2 (0.38) | MAOAMAOBALDH1A1MAPTKMT2A | |
| SCHEMBL8506321 | 0.85 | PTGS2 (0.38) | MAOAMAOBALDH1A1MAPTKMT2A | |
| SCHEMBL2221809 | 0.85 | AKR1C3 (0.37) | MAOAMAOBALDH1A1AKR1C3PTGS2 | |
| SCHEMBL2223831 | 0.85 | PTGS2 (0.32) | AKR1C3PTGS2 | |
| SCHEMBL8796288 | 0.84 | AKR1C3 (0.48) | AKR1C3PTGS2 | |
| SCHEMBL15572432 | 0.84 | PTGS2 (0.34) | ALDH1A1KMT2AMEN1AKR1C3PTGS2 | |
| SCHEMBL15570465 | 0.84 | AKR1C3 (0.39) | MAOBALDH1A1KMT2AMEN1AKR1C3 | |
| SCHEMBL8797000 | 0.83 | AKR1C3 (0.45) | MAOAMAOBALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723442-A4 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS INC (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0723442-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1996003987-A1 | LACTONE COMPOUNDS FOR TREATING PATIENTS WITH PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 1996-02-15 | — | — | WO | disclosed |