Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 3/20 | 0.38 |
| ▸ | CES2 | O00748 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15571625 | 0.87 | AKR1C3 (0.37) | AKR1C3METAP1MAOB | |
| SCHEMBL15570939 | 0.87 | PTGS2 (0.37) | AKR1C3CES2MAOB | |
| SCHEMBL8506321 | 0.85 | PTGS2 (0.38) | AKR1C3MEN1ALDH1A1KMT2AMAOB | |
| SCHEMBL2223120 | 0.85 | PTGS2 (0.38) | AKR1C3MEN1ALDH1A1KMT2AMAOB | |
| SCHEMBL2221809 | 0.85 | AKR1C3 (0.37) | AKR1C3ALDH1A1MAOB | |
| SCHEMBL15572316 | 0.84 | AKR1C3 (0.58) | AKR1C3 | |
| SCHEMBL15572432 | 0.84 | PTGS2 (0.34) | AKR1C3MEN1ALDH1A1KMT2A | |
| SCHEMBL8796929 | 0.84 | MAOA (0.34) | AKR1C3MEN1ALDH1A1KMT2AMAOB | |
| SCHEMBL8603397 | 0.84 | AKR1C3 (0.47) | AKR1C3MIFCES2 | |
| SCHEMBL8435180 | 0.82 | AKR1C3 (0.49) | AKR1C3MIFCES2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882426-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014026959-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2014-02-20 | — | — | WO | disclosed |