Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.62 |
| ▸ | RAB9A | P51151 | 9/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.59 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GCK | P35557 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | METAP1 | P53582 | 1/20 | 0.56 |
| ▸ | SCD | O00767 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28801036 | 0.84 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2MAPTKCNMA1 | |
| SCHEMBL16073076 | 0.83 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2MAPTKCNMA1 | |
| Bromide SCHEMBL27908399 | 0.83 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2MAPTKCNMA1 | |
| SCHEMBL4756204 | 0.82 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2MAPTBRD4 | |
| SCHEMBL8797043 | 0.81 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2MAPTBRD4 | |
| SCHEMBL14018616 | 0.81 | RAB9A (0.72) | NPC1RAB9ASMN1; SMN2MAPTBRD4 | |
| SCHEMBL6918581 | 0.79 | GRM5 (0.59) | NPC1RAB9ASMN1; SMN2MAPTBRD4 | |
| SCHEMBL7693536 | 0.79 | MAPT (0.74) | NPC1RAB9ASMN1; SMN2MAPTKCNMA1 | |
| SCHEMBL6918311 | 0.79 | GRM5 (0.53) | NPC1RAB9ASMN1; SMN2GCKHPGD | |
| SCHEMBL15116290 | 0.79 | KMT2A (0.74) | SMN1; SMN2MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |