SCHEMBL8797193

SCHEMBL8797193

O=C(O)c1ccc(O)c(CCc2ccccc2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
TP53 P04637 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
ALOX12 P18054 1/20 0.50
CYP2C19 P33261 1/20 0.50
CKS1B P61024 1/20 0.50
SKP2 Q13309 1/20 0.50
HIF1A Q16665 1/20 0.50
HSD17B10 Q99714 1/20 0.50
KDM4E B2RXH2 1/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
POLB P06746 1/20 0.50
GAA P10253 1/20 0.50
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8755112 0.89 CA12 (0.61) ALDH1A1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL8408039 0.87 PKM (0.60) ALDH1A1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL11598778 0.84 TSHR (0.53) ALDH1A1HSD17B10KDM4EGAADAO
SCHEMBL9651071 0.84 MEN1 (0.59) CYP3A4HPGDALOX15HIF1AHSD17B10
SCHEMBL8408482 0.83 HPGD (0.70) ALDH1A1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL14312211 0.81 DAO (0.47) ALDH1A1POLBL3MBTL1DAOHDAC1
SCHEMBL8409966 0.81 HSP90AA1 (0.68) ALDH1A1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL8409449 0.81 CA12 (0.59) ALDH1A1TP53CYP1A2CYP3A4CYP2C9
SCHEMBL9487127 0.80 ALOX15 (0.60) CYP3A4HPGDALOX15HIF1AHSD17B10
SCHEMBL27383637 0.79 TSHR (0.51) ALDH1A1HSD17B10KDM4EGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778821-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1997-06-18 EP disclosed
WO-1996006822-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1996-03-07 WO disclosed
EP-0219302-A2 Recording materials FUJI PHOTO FILM CO., LTD. (JP) 1987-04-22 EP disclosed