SCHEMBL8409449

SCHEMBL8409449

CCOC(=O)c1ccc(O)c(CCc2ccccc2)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.59
CA1 P00915 2/20 0.59
CA2 P00918 2/20 0.59
CA7 P43166 2/20 0.59
CA9 Q16790 2/20 0.59
CA14 Q9ULX7 2/20 0.59
L3MBTL1 Q9Y468 2/20 0.58
TDP1 Q9NUW8 1/20 0.58
HSD17B2 P37059 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.52
ALDH1A1 P00352 2/20 0.52
ALOX12 P18054 2/20 0.52
TP53 P04637 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
HPGD P15428 1/20 0.52
ALOX15 P16050 1/20 0.52
CYP2C19 P33261 1/20 0.52
CKS1B P61024 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8408482 0.86 HPGD (0.70) CA12CA1CA2CA7CA9
SCHEMBL1515780 0.84 CA12 (0.68) CA12CA1CA2CA7CA9
SCHEMBL29087481 0.82 LMNA (0.57) CA12CA1CA2CA7CA9
SCHEMBL8418000 0.82 CA12 (0.74) CA12CA1CA2CA7CA9
SCHEMBL8406716 0.82 HTR1A (0.51) L3MBTL1TDP1SMN1; SMN2ALDH1A1HPGD
SCHEMBL2654639 0.81 ALDH1A1 (0.56) CA12CA1CA2CA7CA9
SCHEMBL6274539 0.81 HPGD (0.56) CA12CA1CA2CA7CA9
SCHEMBL8408039 0.81 PKM (0.60) ALDH1A1ALOX12TP53CYP1A2CYP3A4
SCHEMBL9454406 0.81 CYP4F2 (0.73) CA2L3MBTL1TDP1SMN1; SMN2ALDH1A1
SCHEMBL8797193 0.81 ALDH1A1 (0.50) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778821-B1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LTD (GB) 1999-10-20 EP disclosed
US-5965741-A ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES ZENECA LIMITED (GB) 1999-10-12 US disclosed
EP-0778821-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1997-06-18 EP disclosed
WO-1996006822-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1996-03-07 WO disclosed